Endocrine Abstracts

Background: Increasing incidence of thyroid cancer may be attributable to sensitive diagnostic tools as well as changes in exposure to certain environmental factors. Type 2 diabetes mellitus (DM) reaches high prevalence worldwide. DM is a risk factor for many chronic disorders including cardiovascular disease and cancer. Insulin resistance (IR) is a fundamental aspect of the etiology of DM and compensatory hyperinsulinemia could promote cancer growth. The association between D...

Introduction: Langerhans cell histiocytosis (LCH) is a very rare haematological disease, with difficult diagnosis for its very variable clinical picture. It is caused by monoclonal proliferation of cutaneous Langerhans cells. It affects most commonly the skin and bones, less often bone marrow, liver, pituitary and CNS.Case report: A 74-year-old female patient with progressive sclerosing cholangitis was referred to a transplant centre to consider liver tr...

Introduction: The role of vitamin D in GD is poorly understood. The aim was to compare vitamin D levels in newly diagnosed patients with GD with the general population and to correlate vitamin D levels at diagnosis with laboratory and clinical parameters in GD. Moreover, we examined genetic variation in genes involved in the vitamin D metabolism and their association with GD.Material and methods: Levels of vitamin D were compared in 292 patients with new...

The hypo and hyperthyroidism alter the synthesis/secretion of pituitary hormones, which in normal conditions present fluctuations in serum concentration during the 24h period. An intrinsic pituitary circadian clock might be related to these oscillations; however, the possible interaction between thyroid hormonal conditions and circadian clock gene expression in anterior pituitary is still unknown. The purpose of this study was to investigate the expression of core circadian cl...

Myocardial gene expression and metabolism fluctuate over the course of the day, in association with changes in energy supply and demand. Recently, time-of-day-dependent oscillations in myocardial processes have been linked to the intrinsic cardiomyocyte circadian clock. Triiodothyronine (T3) is an important modulator of cardiac form and function. The genomic actions of T3 are triggered after its interaction with thyroid hormone nuclear receptors that ofte...

Background: The prescription of triiodothyronine (T3) for hypothyroidism is increasing worldwide, however, long-term effects of its use are largely unknown. Previous studies have suggested possible association between T3 use and breast cancer. The aim of the study was to examine the effects of T3 use on cancer incidence and mortality.Material: Our sample included the full adult population of individuals living in Sweden with at least three purchases of t...

Objective: Patients with low thyroid peroxidase antibodies (anti-TPO) and increased TSH-receptor antibodies (TRAb) at diagnosis of Graves’ disease (GD) have been suggested to have an increased risk to develop Graves’ ophthalmopathy (GO). The aim was to evaluate if GO development can be predicted.Design: Observational study with registration of possible GD and GO risk factors.Methods: Three hundred and ninety nine patients...

The production and activities of steroid hormones during pregnancy have many interesting aspects. Their synthesis and metabolism are the result of complex metabolic pathways encompassing activities in the fetus, placenta, and mother. Progesterone, estrogens, androgens and glucocorticoids all play important roles during pregnancy, from implantation to delivery. Focusing on selected steroid hormones in the peripartum period, we defined reference ranges measured using LS-MS/MS, a...

Smoking has many effects on human health and reproduction. Women are generally recommended to quit smoking before conception. Cessation improves fertility and helps avoid many health risks for the mother and the child and plays an important role in the future development and health of the offspring. We have decided to perform a study following changes in the production of steroid hormones in pregnant smokers and ex-smokers compared to non-smokers. In physiological pregnancies,...

The ingestion of high-fat diet has been considered a crucial factor in the genesis of subclinical systemic inflammation and insulin resistance. The resistance training (RTr) can be an effective tool for the prevention and treatment of immune-metabolic disorders through physiological and morphological adaptations. The purpose of the present study was to analyze the effects of RTr and cessation of training on muscle inflammation and expression of genes related to glucose metabol...